Yes and no. No Windows applications will run natively on PureOS. However, some Windows applications can be run with an application called Wine. Please go to www.winehq.org to check on the availability of your program. Applications designed for Apple products can not run on a GNU/Linux based machine such as a Librem.
Additionally, you can also run Windows or Apple operating systems within our virtual box application, Boxes, which would allow you to run the applications that you need.
Please also note that Windows based programs run as non-free source/proprietary code and Purism can not offer a guarantee that your Librem will continue to be secure if you choose to install. We do not recommend doing this for your own privacy and security but you are welcome to as the Librem is your machine.